Undereye Polynucleotides in Streatham & Sydenham
Rejuvenate the delicate eye area with Undereye Polynucleotides in Streatham and Sydenham at Dr Mirali Aesthetics. Polynucleotides are bio-stimulators that encourage skin regeneration, boosting collagen and elastin to improve fine lines, pigmentation/dark circles, hydration and elasticity—ideal for common undereye concerns including mild hollowing. Derived from purified fragments of fish DNA (closely resembling human DNA), they’re a filler-alternative for clients who aren’t suitable for, or prefer not to have, tear trough filler. Your plan is tailored by a GMC-registered doctor with clear aftercare at our trusted South London clinics.
Treatment Snapshot
-
Procedure time: ~20–30 minutes
-
Anaesthetic: Topical numbing as needed
-
Downtime: Low (pin-prick swelling/redness 24–48h)
-
Course: Typically 2–3 sessions spaced 3–4 weeks apart
-
Results: Hydration/comfort in weeks; visible skin-quality improvement builds over 4–8+ weeks
What are Polynucleotides?
Polynucleotides are bio-polymers (DNA fragments) that act as bio-stimulators, signalling skin cells to repair and remodel. In the undereye, they improve hydration and elasticity, soften fine lines, and brighten the appearance of dark circles. They do not add structural volume like filler, making them a considerate option when puffiness risk or very thin skin makes filler less suitable.
Best for
-
Fine lines/crepiness under the eyes
-
Dark circles/pigmentation appearance
-
Mild hollowing and decreased elasticity
-
Clients seeking a filler-alternative
Benefits
-
Improves dark circles and brightness
-
Softens fine lines; enhances elasticity
-
Hydrates delicate undereye skin
-
Lower risk vs. filler in suitable cases
-
Doctor-led protocol with minimal downtime
Frequently Asked Questions
Procedure
We recommend a course of 3-4 sessions, carried out 3-4 weeks apart for optimal results.
Maintenance session once every 6-9 Months
Duration & Longevity
Time: 45 Mins – 15mins for procedure
Numbing cream is applied to make the procedure comfortable. We use very fine needles to introduce the solution into the skin.
Downtime
Common side effects and swelling and bruising which settle after a few days
Where can I get Undereye Polynucleotides treatment near me?
At our Streatham and Sydenham clinics in South London:
Interested in this treatment
Get in touch today simply by clicking on the button for a free consultation.
Book AppointmentContact us
Our Clinics
Get in touch today simply by clicking on the button for a free consultation.
Sydenham ClinicStreatham Clinic
Our Aesthetic Treatments
At Dr Mirali Aesthetics, we provide a complete range of doctor-led skin and injectable treatments across our Streatham and Sydenham clinics. From anti-wrinkle injections and dermal fillers to skin boosters, mesotherapy and microneedling, explore our services designed to deliver safe, natural and effective results.
Face Mesotherapy
Infuse the skin with vitamins and hydration to restore radiance and smoothness.
Forehead Lines
Smooth frown lines for a fresher, more youthful look — with natural results.
Obagi Blue Peel
Instant glow with no peeling, redness, or downtime — perfect before events.
Skin Treatment Insights & Guides
Explore expert advice, treatment benefits and real results from our Streatham and Sydenham aesthetics clinics. From Face Mesotherapy to Microneedling and Profhilo, discover how our doctor-led skin treatments can help you achieve healthy, glowing skin.
What Our Patients Say
MissTinks14
3 months ago
I had a Botox treatment with Dr Mirali and I couldn’t be happier with my experience. She is kind, professional and incredibly knowledgeable.
As a South Asian woman, it was really reassuring to find someone who understands my skin, my concerns, and the hereditary factors that can affect it. Dr Mirali took the time to explain everything clearly, answer my questions, and make sure I felt completely comfortable throughout the process.
Knowing she is also a GP gave me extra confidence that I was in safe hands. I felt at ease from the moment I met her, and I really appreciated her thoughtful and professional approach.
I would highly recommend Dr Mirali to anyone looking for a skilled, caring and trustworthy practitioner.
Sam L.
3 months ago
Dr Mirali is incredible! Kind, patient and informative about treatment options. She genuinely listened to what I was looking for and the results have been absolutely spot on. I would also recommend her to anyone who is looking to have their first aesthetic treatment done as her approach is sensible and she recommends what is best for you
Rory C.
3 months ago
I had a really positive experience with Dr. Mirali. She was honest, approachable, and took the time to explain everything clearly. Her skincare recommendations were thoughtful, practical, and tailored to my needs, which gave me a lot of confidence in the treatment plan.
I’m very happy with the advice and care I received, and I would highly recommend Dr. Mirali to anyone looking to improve their skin. She’s professional, knowledgeable, and genuinely cares about helping her patients achieve the best results.
Georgia P.
4 months ago
Had my first microneedling session with Dr. Mirali and am already so happy with the results. She made me feel very comfortable during the session and throughly explained the benefits and risks. The treatment itself was quick and relatively pain free. Glad I found I dermatologist like Dr. Mirali and can’t recommend her enough!
Emma M.
4 months ago
I have had great experience with Dr Mirali so far. She is incredibly knowledgeable, explains everything clearly, and immediately puts you at ease. The treatment was quick, comfortable, and carried out entirely at my pace, with no pressure whatsoever. I felt fully informed and confident throughout the process and would highly recommend her to anyone considering aesthetic treatments.
Debra S.
4 months ago
I had a great experience with Dr Mirali, I am really happy, we talked in detail about a skincare routine which I am now following, she is very knowledgeable. I had Botox, the best I’ve had for years, very natural and no droopy brows.
Happy to have found her ????
Veronika H.
5 months ago
Dr. Mirali was incredibly professional and knowledgeable. My results were natural – just as requested. Recommend.
Marga M.
6 months ago
Today I had my first consultation with Dr. Mirali, and I couldn't be more happier.
Never before in my previous experiences with dermatologists or esthetic doctors had my case, skin type, possible treatments, habits, etc., been explained to me in such detail.
She is very friendly, attentive, and knowledgeable; you can tell she's passionate about her work. I'm really looking forward to starting the treatment. I recommend her 100%.
Marta Bueno G.
6 months ago
Couldn’t be any happier with Dr Mirali!
I have had masseter botox done with her a couple of times, and since I had a great experience, I felt confident to do my first filler treatment with her.
I had noticed that in the last few years my under-eye area was looking more tired, and wanted to do something about it.
Having been to other injectors in the past for masseter botox (didn’t have very good experiences), I had been told I could do tear trough filler to improve it.
Dr Mirali assessed my face, feeling the bone and muscles around my eye and explained that because of the oedema I have around my eyes, that would not be recommended as it could make it look more prominent and give the impression that my eyes bags are worse.
Instead she suggested we did filler in the mid face to improve the volume loss that has happened over time, which is what made my skin around the eye fall and look tired.
The procedure was explained perfectly with all the risks and possible complications before she started. I felt super safe in her hands the whole time and even when I felt a bit faint she was so kind and empathetic, I felt so comfortable. She checked that I had good blood flow to area right after the treatment and checked on me afterwards to make sure I was doing well. I only had very minor discomfort and swelling but not even noticeable.
The results have been amazing! People that know me don’t even notice what treatment I had done, they just say I look like a had a very good night sleep!
I’m so glad I found such a good professional, she clearly loves what she does and is very knowledgeable.
It’s scary when you have so many people offering procedures that would not have worked for my type of eye.
I look forward to using all of the skincare she has recommended and see the final results in a few months to a year!
Finding a good doctor makes you realise how important it is to be able to trust your injector and feel safe.
If you want natural results that are part of a long-term plan to enhance your natural beauty without changing your face, Dr Mirali is your person ✨
Thank you so much!
Kinga S.
6 months ago
I was really nervous before my appointment, but Dr. Mirali made me feel so calm and safe from the first moment. She took her time to understand exactly what I wanted and didn’t rush anything. I asked for a natural look and that’s exactly what I got — I still look like myself, just better. Even after one day, I’m already so happy with the result. You can tell she’s very skilled and truly cares about her clients. I would definitely trust her again.
Toyin
7 months ago
I was referred to Dr Mirali by my dentist due to pain from grinding my teeth and clenching my jaw. From the moment I arrived, Dr Mirali was incredibly professional, friendly, and reassuring. She took the time to explain everything clearly, which meant so much to me especially as I have a fear of needles.
The treatment was smooth, comfortable, and truly seamless, and I felt completely at ease throughout. I’ve already noticed such a positive difference.
I honestly couldn’t recommend Dr Mirali Aesthetics more. A fantastic experience from start to finish!
Nia B.
7 months ago
Dr Mirali was so lovely and made me feel really comfortable. The consultation was thorough and I am looking forward to continuing with the treatments!
Louise H.
8 months ago
Amazing lady, explained everything in fine detail, and helped me with my skin care... would recommend
Sana S.
8 months ago
I had an excellent experience at Dr Mirali Aesthetics. From the moment I walked in, I felt welcomed and completely at ease. Dr Mirali is incredibly knowledgeable, professional, and takes the time to really listen and understand what you want, while offering honest and expert advice.
The treatment was explained clearly, carried out with great care, and the results look natural and beautifully done. I never felt rushed, and the attention to detail was outstanding.
I’m beyond happy with my results and would highly recommend Dr Mirali Aesthetics to anyone looking for high-quality, safe, and professional aesthetic treatments.
Jainisha P.
8 months ago
I’ve just had my first microneedling treatment with Dr Mirali and I’m already really impressed with the results. My skin looks brighter, smoother, and more refreshed after just one session.
Dr Mirali was professional, thorough, and made me feel completely at ease, explaining everything clearly before and during the treatment. I’m genuinely excited to continue my skin journey with her and would highly recommend her to anyone considering microneedling or aesthetic treatments.
Angela
9 months ago
Dr Mirali is very kind and professional, and put me at ease. She is also a GP and walked me through the consultation and asked if I had any questions along the way . This is the first time I have had Botox on frown lines and I am pleased to say that I don't look like the 'Stepford wives' - it looks very natural and there are no lines, hurrah! The injections did not hurt at all thank goodness. I would highly recommend.
This Fabled P.
9 months ago
Went to Dr Mirali for frown lines and had treatment. She explained everything thoroughly, answered all my questions and put me at ease. She reassured me I could contact her any time after treatment if needed. Also, as a woman of colour I feel happier seeing Dr Mirali as I feel she understands issues with ethnic skin better. Highly recommend!
H D (.
9 months ago
I had a Perfect Peel facial 2 days ago and my face has started to peel on day 3, which I felt well prepared for thanks to the clear aftercare advice. Dr Marali also put me on a skin-prep regimen before the peel, which I really appreciated. Dr Marali was professional, knowledgeable and reassuring, explaining each step clearly and making sure I felt comfortable throughout. Very professional and reassuring — looking forward to the full results.
Stephanie W.
11 months ago
My experience with Dr Mirali has been extremely positive. She’s very approachable and is clearly an expert in her field. She explained the treatment thoroughly, answered my many questions, and provided a detailed skincare plan. Would definitely recommend.
Reena P.
11 months ago
A wonderful experience! I visited Dr Mirali after my skin became very reactive to light. We went through what was happening with my skin, the products I was using, possible treatments and other things I can do to minimise reactions. I’ve been using the treatment Dr Mirali recommended for a month or so and have already noticed a big difference in my skin.
tasneem F.
1 year ago
Dr Mirali is clearly very knowledgeable and was incredibly informative during the consultation. She took time to gauge my own understanding of treatments and procedures, addressed any misconceptions I had, answered my endless questions about various things related to skincare and was honest and upfront about risks, recovery and detailed expectations for the outcomes I’m seeking. I felt comfortable the whole time, and left feeling more confident to be able to make an informed decision about delving deeper into the field of professional skincare, especially with her extensive experience and knowledge as a medical practitioner.
Her process is very streamlined and I was provided with a detailed skincare plan that aligned with everything we had discussed during the consultation. Whether new to professional skincare or well-versed, Dr Mirali is able to adapt and accommodate to all levels of expertise. I never felt like I’m being talked down to or that I was only receiving half-baked, basic answers to my questions. I’d recommend this to anybody looking for comprehensive guidance and recommendations, and a clinician who prioritises patient safety.
Gloria S.
1 year ago
Dr Mirali was very professional informative and friendly . I had Botox with no bruising and very natural effect. I’m very happy with the result . Highly recommend her.
Saeeda C.
1 year ago
My first experience was excellent explanation was brilliant I m really happy looking forward to see again.
Bijal P.
1 year ago
I was recommended to Dr. Mirali through my sister. She was extremely helpful and very friendly. She offered a variety of treatments, and I decided to try polynucleotides. Very reasonable priced and competitive with others. I've noticed a huge difference in the quality of my under eye bags. We did discuss all suitable options, she was very knowledgeable and steered me in the right direction. Would definitely recommend
Louise H.
1 year ago
I went to Dr Mirali when my dentist thought it might help with my jaw pain. I was willing to give it a go because my jaw ached all the time and it was limiting what I could eat. I found Dr Mirali to be calm and professional - she explained the botox procedure clearly. Although the actual injections were quite painful, it was over very quickly. My jaw felt much more comfortable within a few days and I've now been pain-free for 3 months. Botox injections are quite expensive, and I don't know when I'll need more - but I definitely would spend the money with Dr Mirali again. Very happy with the service and the results! ????
kajal P.
1 year ago
I had a virtual appointment and face to face appointment with Dr Mirali and she was so welcoming and easy to talk to. She listened to what support I wanted and explained each process, including how to use the products she recommended. Within 2 weeks of being consistent I have already noticed a change to my skin. I would definitely recommend using Dr Mirali and using her simple but effective treatment plan.
Kumari T.
2 years ago
The skin consultation was really good! The way she communicated with both me and my mum was impressive. She did a deep dive into my skin issues and explained how to take care of my skin in a straightforward manner. I appreciated that she focused on a routine instead of jumping straight to chemical peels, which is often what other consultations do. It’s so important for clients to understand the basics first, and I feel like she did a great job at implementing a routine that suits my needs and my mum needs. I’ve always wanted rejuvenated skin but was often confused about the right steps to take. Overall, she really helped simplify things for me And my mum!
Alexandra J.
2 years ago
Dr Mirali is fabulous - had a great consultation ahead of getting masseter botox. I was really keen to book her because of her GP background, and I felt in safe hands the whole way. She took the time to learn about my medical history and background before we even got to the skin/treatment consultation. She was fantastic in the treatment appointment too, answered my many (and usually silly) questions and has stayed in touch to see how the treatment has settled. Would definitely recommend.
Sophia N
2 years ago
Dr Mirali was very knowledgable about my treatment and helped in answering all of my questions both before and after the masseter injections. Thank you!
muna D.
2 years ago
Dr. Mirali has been a godsend. I saw her last winter and again in the summer. She uses a very individual and personalized approach to coming up with a plan for her every client. Her conservative yet effective approach to aesthetics is exactly what I was looking for. She takes a holistic view of treating your skin through a comprehensive regime as well as treatments.She is very thorough and explains every step and every procedure. Her hands very light and as such I did not feel much pain during any of my procedures. She follows up regular and is always available for any question or concerns post treatment. I have recommended Dr. Mirali to my friends and would encourage anyone to book with her. You will mot be sorry.
Dee S
2 years ago
Dr Mirali is fantastic, and takes the time to explain every part of the process in a professional manner. In less than 6 months she has helped to improve the qualify of my skin significantly (I had lots of hyperpigmentation from acne scaring), without damaging the integrity of my skin. She is enthusiastic about what she does and it shows with how much care and effort she puts in. My skin has always been something I was self conscious of without make up, but she’s helped me restore my confidence.
Maternity Leave Notice
Dr Mirali will be taking a short maternity break from 1st October to 1st December.
During this time, please be patient with responses, as there may be a slight delay in replying to messages and enquiries.
On Monday 23rd November, Dr Mirali will open her availability on Glowday for bookings in December.
Thank you so much for your patience, understanding and continued support.